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助教

清島 亮

清島 亮
良悪性を問わず、大腸・小腸疾患に対する手術治療を専門的に行っています。安全で質の高い外科手術が提供できるよう、また患者さんそれぞれに合った最適な治療を受けて頂けるよう、常に心がけて診療に当たっています。

  • 日本外科学会専門医
  • 日本消化器外科学会専門医・指導医
  • 臨床研修指導医
  • 日本内視鏡外科学会技術認定医（大腸）

経歴

2007年 平塚市民病院　初期臨床研修医
2009年 慶應義塾大学医学部外科学教室　入局
練馬総合病院　外科
2010年 水戸赤十字病院　外科
2011年 慶應義塾大学医学部　一般・消化器外科　専修医
慶應義塾大学医学部　大学院(博士)入学
2015年 永寿総合病院　外科
慶應義塾大学医学部　大学院卒業，学位(博士)取得
2016年 シンガポール　Agency for Science, Technology and Research (A*STAR), Institute of Medical Biology (IMB), Epithelial Stem Cell Group, Senior Research Fellow
2019年

慶應義塾大学医学部　一般・消化器外科　助教
2022年

藤田医科大学医学部　客員講師

主たる研究内容

  • 年齢リスクに応じた大腸疾患治療の最適化
  • 大腸癌における癌幹細胞の役割と、治療標的としての有用性の検討

資格

  • 日本外科学会専門医
  • 日本消化器外科学会専門医・指導医
  • 消化器がん外科治療認定医
  • 日本がん治療認定医機構がん治療認定医
  • 身体障害者手帳指定医(膀胱・直腸)
  • 臨床研修指導医
  • 日本内視鏡外科学会技術認定医（大腸）
  • ロボット手術(ダヴィンチ)トレーニングコース修了

所属学会

  • 日本外科学会
  • 日本消化器外科学会
  • 日本内視鏡外科学会
  • 日本大腸肛門病学会
  • 日本癌治療学会
  • 日本癌学会

助成金

2020年 文部科学省科学研究費　若手研究 「炎症性腸疾患の粘膜治癒過程における浸透圧変化の影響」

高松宮妃癌研究基金研究助成 「大腸癌肝転移における癌関連線維芽細胞出現メカニズムの解明」

かなえ医薬振興財団研究助成 「癌幹細胞ニッチを標的とした大腸癌肝転移に対する新規治療の検討」

武田科学振興財団医学系研究助成 「大腸癌肝転移時の癌関連線維芽細胞出現メカニズムに関する研究」
2021年 横山臨床薬理研究助成基金　一般研究　「大腸癌肝転移における幹細胞ニッチとしての癌関連肝線維芽細胞の出現メカニズムに関する研究」
2022年 文部科学省科学研究費　若手研究「浸透圧応答遺伝子が潰瘍性大腸炎の腸管免疫に与える影響」

受賞歴

2012年

2021年		 10th International Conference of the Asian Clinical Oncology Society, Merit Award
第59回日本癌治療学会学術集会　最優秀演題賞
第80回日本癌学会学術総会　JCA若手研究者ポスター賞

論文

    • 1. Kato H, Seishima R, Nakamura K, Matsui S, Shigeta K, Okabayashi K, Kitagawa Y. The Prognostic Nutritional Index is a Predictive Marker for Postoperative Complications in Patients with Late-Onset Ulcerative Colitis. World J Surg. 2023 Jul 20.
    • 2. Takeuchi M, Endo H, Hibi T, Seishima R, Nakano Y, Yamamoto H, Miyata H, Maeda H, Hanazaki K, Taketomi A, Kakeji Y, Seto Y, Ueno H, Mori M, Kitagawa Y. Analysis of the short-term outcomes after esophagectomy for esophageal cancer during the COVID-19 pandemic using data from a nationwide Japanese database. Esophagus. 2023 Jun 22.
    • 3. Sakamoto K, Okabayashi K, Matsumoto S, Matsui S, Seishima R, Shigeta K, Kitagawa Y. Drainage pattern of the splenic flexure vein and its accompanying arteries using three-dimensional computed tomography angiography: a single-centre study of 600 patients. Colorectal Dis. 2023 May 23. 
    • 4. Sugiura K, Seo Y, Tajima Y, Kikuchi H, Hirata A, Nakadai J, Baba H, Kondo T, Makino A, Kato Y, Matsui S, Seishima R, Shigeta K, Okabayashi K, Kitagawa Y. Prognostic Impact of Main Lymph Node Metastasis in Patients with Colon Cancer. World J Surg. 2023 Jan 23.
    • 5. Sasaki T, Shigeta K, Matsui S, Seishima R, Okabayashi K, Kitagawa Y. Mesenteric location of lymph node metastasis for colorectal cancer. ANZ J Surg. 2023.
    • 6. Seishima R, Okabayashi K, Ikeuchi H, Uchino M, Futami K, Noguchi T, Ohge H, Iseki Y, Watanabe K, Itabashi M, Okamoto K, Toiyama Y, Ogino T, Nakamura M, Yamada K, Wakai T, Sato Y, Kimura H, Takahashi K, Hida K, Kinugasa Y, Ishida F, Okuda J, Daito K, Koyama F, Ueno H, Yamamoto T, Yamamoto S, Hanai T, Maemoto A, Arakaki J, Komori K, Akagi Y, Shida D, Yamaguchi S, Matsuda K, Maeda K, Noake T, Nezu R, Sasaki S, Hasegawa J, Sunami E, Kanemitsu Y, Katsumata K, Uehara K, Kiyomatsu T, Suto T, Kazama S, Yamada T, Goi T, Ishihara S, Ajioka Y, Sugihara K. Effect of Biologics on the Risk of Advanced-Stage Inflammatory Bowel Disease-Associated Intestinal Cancer: A Nationwide Study. Am J Gastroenterol. 2023.
    • 7. Sasaki T, Shigeta K, Kitahara S, Suzuki Y, Matsui S, Seishima R, Okabayashi K, Duda DG, Kitagawa Y. Inhibition of STAT3 Promotes Effector T Cell Infiltration But also Immunosuppression in the HCC Tumor Microenvironment. Anticancer Res. 2022 Nov;42(11):5205-5215.
    • 8. Suzuki Y, Okabayashi K, Hasegawa H, Tsuruta M, Seishima R, Tokuda T, Kitagawa Y. Role of EphB2/ephrin-B1 signalling in the development and progression of obesity-associated colorectal cancer. Oncol Lett. 2022 Jul 19;24(3):316.
    • 9. Sakamoto K, Okabayashi K, Matsui S, Seishima R, Shigeta K, Kitagawa Y. Association of Tumor Pathological Response with the Use of Metformin During Neoadjuvant Chemoradiotherapy in Rectal and Esophageal/Gastroesophageal Cancer Patients: a Systematic Review and Meta-analysis. J Gastrointest Surg. 2022 Jul. 
    • 10. Ogiri M, Seishima R, Nakamura K, Aimono E, Matsui S, Shigeta K, Chiyoda T, Tanishima S, Okabayashi K, Nishihara H, Kitagawa Y. Real-world application of next-generation sequencing-based test for surgically resectable colorectal cancer in clinical practice. Future Oncol. 2022 Jul.
    • 11. REACCT Collaborative. Impact of microsatellite status in early-onset colonic cancer. Br J Surg. 2022 Jun ;109(7):632-636.
    • 12. REACCT Collaborative. Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer. Front Oncol. 2022 May.
    • 13. Sugiura K, Okabayashi K, Seishima R, Ishida T, Shigeta K, Tsuruta M, Hasegawa H, Kitagawa Y. Metformin inhibits the development and metastasis of colorectal cancer. Med Oncol. 2022 Jul ;39(9):136.
    • 14. Kato Y, Shigeta K, Tajima Y, Kikuchi H, Hirata A, Nakadai J, Sugiura K, Seo Y, Kondo T, Okui J, Matsui S, Seishima R, Okabayashi K, Kitagawa Y. Comprehensive risk score of the E-PASS as a prognostic indicator for patients after elective and emergency curative colorectal cancer surgery: A multicenter retrospective study. 2022 Apr 18;101.
    • 15. Nakamura K, Seishima R, Emoto K, Kawahara T, Matsui S, Shigeta K, Okabayashi K, Hosoe N, Kitagawa Y. The development of colon adenocarcinoma on a ganglioneuroma in a patient with nonhereditary disease. Am J Gastroenterol. 2022.
    • 16. Mizuno S, Okabayashi K, Ikebata A, Matsui S, Seishima R, Shigeta K, Kitagawa Y. Prediction of pouchitis after ileal pouch-anal anastomosis in patients with ulcerative colitis using artificial intelligence and deep learning. Tech Coloproctol. 2022.
    • 17. Nakamura K, Seishima R, Matsui S, Shigeta K, Okabayashi K, Kitagawa Y. The prognostic impact of preoperative mean corpuscular volume in colorectal cancer. Jpn J Clin Oncol. 2022.
    • 18. REACCT Collaborative. Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response. Br J Surg. 2022 Feb 24;109(3):251-255.
    • 19. Mizuno S, Seishima R, Yamasaki J, Hattori K, Ogiri M, Matsui S, Shigeta K, Okabayashi K, Nagano O, Li L, Kitagawa Y. Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer. J Cancer Res Clin Oncol. 2022.
    • 20. Tsunoda J, Shigeta K, Matsui S, Seishima R, Okabayashi K, Kitagawa Y. Neutrophil-to-Lymphocyte Ratio is a Useful Biomarker for Predicting Postoperative Complications in Crohn's Disease. J Gastrointest Surg. 2022.
    • 21. Morita S, Tsuruta M, Okabayashi K, Shigeta K, Seishima R, Monno M, Itano O, Kitagawa Y. Evaluation of abdominal aortic calcification by plain CT predicts anastomotic leakage in laparoscopic surgery for colorectal cancer. Jpn J Clin Oncol. 2021.
    • 22. Suzumura H, Tsuruta M, Okabayashi K, Shigeta K, Seishima R, Ishida T, Shimada T, Asada Y, Koishikawa K, Akimoto S, Itano O, Hasegawa H, Kitagawa Y. BAF57 Is a Potential Determinant of Colorectal Cancer Malignancy. Anticancer Res. 2021;41(11):5445-5452.
    • 23. BJS Commission Team. BJS commission on surgery and perioperative care post-COVID-19. Br J Surg. 2021;108(10):1162-1180.
    • 24. REACCT Collaborative. Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review. JAMA Surg. 2021;156(9):865-874.
    • 25. Ikebata A, Okabayashi K, Tsuruta M, Shigeta K, Seishima R, Shimoda M, Naganuma M, Kitagawa Y. Colectomy risk score predicts pouchitis in patients with ulcerative colitis. Updates Surg. 2021.
    • 26. Matsuoka S, Kondo T, Seishima R, Okabayashi K, Tsuruta M, Shigeta K, Ishida T, Hasegawa H, Kitagawa Y. Surgical glove perforation during laparoscopic colorectal procedures . Surg Endosc. 2021;11:1-6.
    • 27. Sasaki T, Shigeta K, Okabayashi K, Tsuruta M, Seishima R, Matsui S, Kitagawa Y. Horizontal spread of pericolic lymph node metastasis as a prognostic factor for recurrence in Stage Ⅲ colorectal cancer. Colorectal Dis. 2021;23(6):1370-1378.
    • 28. Morita S, Tsuruta M, Okabayashi K, Ishida T, Shigeta K, Seishima R, Itano O, Hasegawa H, Kitagawa Y. Impact of intraoperative hypocapnia on postoperative complications in laparoscopic surgery for colorectal cancer. Surg Today. 2021.
    • 29. Kato Y, Shigeta K, Okabayashi K, Tsuruta M, Seishima R, Matsui S, Sasaki K, Koseki Y, Kitagawa Y. Lymph noge metastasis is strongly associated with lung metastasis as the first recurrence site in colorectal cancer. Surgery. 2021;S0039-6060(21).
    • 30. Seishima R, Miyata H, Okabayashi K, Hasegawa H, Tsuruta M, Shigeta K, Monno M, Yamashita Y, Inomata M, Wakabayashi G, Kakeji Y, Kitagawa Y, Watanabe M. Safety and feasibility of laparoscopic surgery for elderly cancer patients in Japan：a nationwide study. BJS Open. 2021;5(2).
    • 31. Mizuno S, Seishima R, Okabayashi K, Shigeta K, Matsui S, Kitagawa Y. Sarcopenic obesity is a postoperative prognostic factor for stage Ⅱ and Ⅲ colorectal cancer. J Gastrointest Surg. 2021.
    • 32. Ikebata A, Okabayashi K, Tsuruta M, Shigeta K, Seishima R, Naganuma M, Kitagawa Y. The utility of the colectomy risk score in terms of predicting postoperative complications in patients with ulcerative colitis. J Gastrointest Surg. 2020.
    • 33. Makino A, Tsuruta M, Okabayashi K, Ishida T, Shigeta K, Seishima R, Ikebata A, Koishikawa K, Hasegawa H, Shimoda M, Fukunaga K, Betsuyaku T, Kitagawa Y. The Impact of Smoking on Pulmonary Metastasis in Colorectal Cancer. Onco Targets Ther. 2020;13:9623-9629.
    • 34. Tan SH, Swathi Y, Tan S, Goh J, Seishima R, Murakami K, Oshima M, Tsuji T, Phuah P, Tan LT, Wong E, Fatehullah A, Sheng T, Ho SWT, Grabsch HI, Srivastava S, Teh M, Denil SLIJ, Mustafah S, Tan P, Shabbir A, So J, Yeoh KG, Barker N. AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature. 2020 Feb;578(7795):437-443.
    • 35. Seishima R, Leung C, Yada S, Murad KBA, Tan LT, Hajamohideen A, Tan SH, Itoh H, Murakami K, Ishida Y, Nakamizo S, Yoshikawa Y, Wong E, Barker N. Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development. Nat Commun. 2019 Nov 26;10(1):5378.
    • 36. Matsui S, Okabayashi K, Tsuruta M, Shigeta K, Seishima R, Ishida T, Kondo T, Suzuki Y, Hasegawa H, Shimoda M, Sugimoto S, Sato T, Kitagawa Y. Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis. Cancer Sci. 2019 Jul;110(7):2156-2165.
    • 37. Seishima R, Barker N. A contemporary snapshot of intestinal stem cells and their regulation. Differentiation. 2019 Jul - Aug;108:3-7.
    • 38. Saito Y, Onishi N, Takami H, Seishima R, Inoue H, Hirata Y, Kameyama K, Tsuchihashi K, Sugihara E, Uchino S, Ito K, Kawakubo H, Takeuchi H, Kitagawa Y, Saya H, Nagano O. Development of a functional thyroid model based on an organoid culture system. Biochem Biophys Res Commun. 2018 Mar 4;497(2):783-789.
    • 39. Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H, Nagano O. The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-). Cancer Res. 2016 May 15;76(10):2954-63.
    • 40. Seishima R, Okabayashi K, Nagano O, Hasegawa H, Tsuruta M, Shimoda M, Kameyama K, Saya H, Kitagawa Y. Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer. Clin Res Hepatol Gastroenterol. 2016 Sep;40(4):487-93.
    • 41. Shigeta K, Okabayashi K, Hasegawa H, Tsuruta M, Seishima R, Kitagawa Y. Meta-analysis of laparoscopic surgery for recurrent Crohn's disease. Surg Today. 2016 Aug;46(8):970-8.
    • 42. Yamada T, Okabayashi K, Hasegawa H, Tsuruta M, Yoo JH, Seishima R, Kitagawa Y: Meta-analysis of the risk of small bowel obstruction following open or laparoscopic colorectal surgery. Br J Surg. 2016 Apr;103(5):493-503.
    • 43. Seishima R, Uraoka T, Hasegawa H, Okabayashi K, Tsuruta M, Hayashi Y, Kitagawa Y. Colon cancer arising from a sessile serrated adenoma/polyp detected on positron emission tomography/computed tomography. Gastrointest Endosc. 2015 Oct;82(4):760-1.
    • 44. Seishima R, Wada T, Tsuchihashi K, Okazaki S, Yoshikawa M, Oshima H, Oshima M, Sato T, Hasegawa H, Kitagawa Y, Goldenring JR, Saya H, Nagano O. Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis. Cancer Prev Res (Phila). 2015 Jun;8(6):492-501.
    • 45. Seishima R, Okabayashi K, Hasegawa H, Tsuruta M, Hoshino H, Yamada T, Kitagawa Y. Computed tomography attenuation values of ascites are helpful to predict perforation site. World J Gastroenterol. 2015 Feb 7;21(5):1573-9.
    • 46. Seishima R, Okabayashi K, Hasegawa H, Tsuruta M, Shigeta K, Matsui S, Yamada T, Kitagawa Y. Is laparoscopic colorectal surgery beneficial for elderly patients? A systematic review and meta-analysis. J Gastrointest Surg. 2015 Apr;19(4):756-65.
    • 47. Seishima R, Okabayashi K, Hasegawa H, Sugiyama D, Ishii Y, Tsuruta M, Takebayashi T, Kitagawa Y. Obesity was associated with a decreased postoperative recurrence of rectal cancer in a Japanese population. Surg Today. 2014 Dec;44(12):2324-31.
    • 48. Hasegawa H, Okabayashi K, Watanabe M, Ashrafian H, Harling L, Ishii Y, Sugiyama D, Seishima R, Darzi A, Athanasiou T, Kitagawa Y. What is the effect of laparoscopic colectomy on pattern of colon cancer recurrence? A propensity score and competing risk analysis compared with open colectomy. Ann Surg Oncol. 2014 Aug;21(8):2627-35.
    • 49. Fierro S, Seishima R, Nagano O, Saya H, Einaga Y. In vivo pH monitoring using boron doped diamond microelectrode and silver needles: application to stomach disorder diagnosis. Sci Rep. 2013 Nov 19;3:3257.
    • 50. Wada T, Ishimoto T, Seishima R, Tsuchihashi K, Yoshikawa M, Oshima H, Oshima M, Masuko T, Wright NA, Furuhashi S, Hirashima K, Baba H, Kitagawa Y, Saya H, Nagano O. Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia. Cancer Sci. 2013 Oct;104(10):1323-9.
    • 51. Seishima R, Ishii Y, Hasegawa H, Endo T, Ochiai H, Okabayashi K, Mukai M, Kitagawa Y. Large liposarcoma developing in the ischiorectal fossa: Report of a rare case. Int J Surg Case Rep. 2013;4(1):51-3.
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